You can make variables that aren't part of the state. It's generally recommended that you use the setup object for things like this.
<<set setup.var to "blah">>
If that for some reason won't work for you, then you can use the Config.saves.onLoad property to create a single use task object to reset or otherwise change story variables when the game is loaded. I can write you up an example of that if needed, but I think just using the setup object or similar is your best bet, depending on what you're doing.