I am just starting out with this and was making a test story to figure things out. I already ran into a problem. Testing the story from the play button in Twine loads it just fine. But after I publish the story to an HTML file on my desktop and try to open it I just get a blank black window. I opened the developer console on chrome and it had this error: "Uncaught DOMException: Failed to read the 'localStorage' property from 'Window': Access is denied for this document."
It loads just fine in Firefox and Explorer.